Zhe Lu

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University of Pennsylvania, Philadelphia, PA, USA

Our laboratory investigates both the fundamental mechanisms of ion channels and the pathogenesis of ion channel-based genetic diseases such as cystic fibrosis and diabetes, and develops novel pharmacological agents to control the activity of specific types of ion channels. Ion channels are a class of highly specialized membrane proteins that allow ions to flow across the cell membrane in a selective manner. The opening and closing of ion channels are precisely regulated by the intricate cell signaling system. Ionic currents through ion channels generate electrical voltage across the cell membrane which underlies the electrical impulses in nerve, muscle and endocrine cells.

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03 Aug 2014

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